Innate immunity against pathogen infection by membrane-localized receptors is evolutionarily conserved among eukaryotes. In plants, innate immunity is essential for defending against harmful microbes that cause dramatic losses in agriculture. Activation of plant immunity is generally determined by pattern-recognition receptors (PRRs). In contrast to mammals, all known plant PRRs are localized at the cell surface. There, they detect potentially harmful microbes by recognizing microbe-associated molecular patterns (MAMPs). PRRs such as receptor-like kinases (RLKs) and receptor-like proteins (RLPs). Activation of innate immunity by membrane-localized receptors is conserved across eukaryotes. Plant genomes contain hundreds of such receptor-like genes and those encoding proteins with an extracellular leucine-rich repeat (LRR) domain represent the largest family. The LRR receptor-like protein Response to XEG1 (RXEG1) from the plant Nicotiana benthamiana,specifically recognizes the glycoside hydrolase 12 protein XEG1. RXEG1 associates with XEG1 via the LRR domain in the apoplast and forms a complex with the LRR receptor-like kinases BAK1 and SOBIR1 to transduce the XEG1-induced defense signal. Here you can see the structure of the RXEG1 protein, with its characteristic "S-shape" in complex with the glycoside hydrolase XEG1 (yellow ribbons), determined by cryoEM (PDB code: 7DRC)
#molecularart ... #immolecular ... #plant ..#defense ... #receptor ... #RXEG1 ... #XEG1 ... #cryoem
Structure of the ligand-receptor complex rendered with @proteinimaging and depicted with @corelphotopaint
#molecularart ... #immolecular ... #plant ..#defense ... #receptor ... #RXEG1 ... #XEG1 ... #cryoem
Structure of the ligand-receptor complex rendered with @proteinimaging and depicted with @corelphotopaint
