Cover published Developmental Cell, 2020
Based on Matsubayashi Y. and Sánchez-Sánchez B.J. et al. Rapid homeostatic turnover of embryonic ECM during tissue morphogenesis
Commissioned by Brian Stramer Laboratory, King's College London
(London, UK)
A crocheted garment represents the extracellular matrix (ECM), which is a complex polymer network thought to form a stable cellular scaffold. The magenta patch represents the newly identified flux in ECM components. Cover image created by composition of real photographs, created using Adobe Photoshop
Cover highlighted in “Voices: voicing the story behind the cover”
in Developmental Cell, 2022
Based on Simões A.R. et al. Damage-responsive neuro-glial clusters coordinate the recruitment of dormant neural stem cells
Commissioned by Christa Rhiner Laboratory, Champalimaud Foundation (Lisbon, Portugal)
Long range damage response in the neural system artwork inspired by japanese animation. Broken leaves floating in a lake represent an area of damaged neurons, from there, Koi carps carry signals to neural progenitors (eggs) to activate proliferation
Cover proposal based on Stapornwongkul K.S. et al. Patterning and growth control in vivo by an engineered GFP gradient. Science, 2020
Commissioned by Jean-Paul Vincent Laboratory, The Francis Crick Institute (London,UK)
New genetic bioengineering tools to analyse signaling pathways in Drosophila melanogaster
Cover proposal based on Díaz-Torres A. et al. Stem cell niche organization in the Drosophila ovary requires the ECM component Perlecan. Current Biology, 2021.
Commissioned by Acaimo González-Reyes Laboratoy, Centro Andaluz de Biología del Desarrollo, CSIC-CABD (Seville, Spain)
Hummingbirds building their nest represent somatic cells depositing the extracellular component perlecan in the stem cell niche
Cover proposals based on Diaz de la Loza M.C. and Stramer B.M. The extracellular matrix in tissue morphogenesis: No longer a backseat driver. Cell & Development review, 2024
1
Composition using the model organisms shown in the review as examples of extracellular matrix shaping tissues
2
Cupcake cartoon to represent the tissue (orange) being shaped by the extracellular matrix (green)
3
Corset to represent extracellular matrix shaping tissues. The embroidery shows model organisms shown in the review as examples
Cover proposal based on Serna-Morales E., Sánchez-Sánchez B.J., Stefania Marcotti S. et al. Extracellular matrix assembly stress initiates Drosophila central nervous system morphogenesis. Developmental Cell, 2023
Commissioned by Brian Stramer Laboratory, King's College London (London, UK)
Sausage making represent how the extracellular matrix (green) that surrounds the embryonic fly brain (pink) shapes the tissue
into an elongated structure.
Cover proposal based on Bartel P. et al. Colourfulness as a possible measure of object proximity in the larval zebrafish brain. Current Biology, 2021
Commissioned by Tom Baden Laboratory, School of Life Sciences University of Sussex (UK)
Photographs arranged to represent the study of vision in zebrafish. The coloured pebbles reveal a pattern of concentric circles only visble by individuals with certain colour blindness
Cover proposals based on Matsubayashi Y. and Sánchez-Sánchez B.J. et al. Rapid homeostatic turnover of embryonic ECM during tissue morphogenesis. Developmental Cell, 2020
Commissioned by Brian Stramer Laboratory, King's College London (London, UK)
1
Extracellular matrix turnover represented as the simultaneous assembly and disassembly of an Andalusian tile mosaic
2
Extracellular matrix turnover represented as the flow of water
through a sea shell
Cover proposal based on Diaz-de-la-Loza M.C. et al.
Control of tissue morphogenesis by the HOX gene Ultrabithorax. Development, 2020.
Charcoal painting to represent changes in gene regulation that have shaped the ancestral insect second pair of wings into halteres in flies and mosquitoes.
Cover proposals based on Diaz-de-la-Loza M.C. et al. Cell Reports, 2017. Laminin levels regulate tissue migration and anterior-posterior polarity during egg morphogenesis in Drosophila.
1
Microscopy images of Drosophila of concatenated developing eggs. Egg rotation - which results in egg elongation- is indicated by arrows
2
3-D rendering of concatenated developing fly eggs, created with Imaris software. The extracellular matrix surrounding the eggs (green) is essential for egg rotation, and therefore elongation. Cell nuclei are shown in blue and cell membranes in yellow.
Cover proposal based on García Rodríguez N. et al. Impaired manganese metabolism causes mitotic misregulation. The Journal of Biological Chemistry, 2012.
Microscopy images edited to represent the effect of manganese misregulation in budding yeast affecting cell size and nucleus morphology
